Glazkova E N, Inyushkin A N
Samara State University, Russia.
Neurosci Behav Physiol. 2006 May;36(4):403-8. doi: 10.1007/s11055-006-0031-y.
Acute experiments were performed on urethane-anesthetized adult laboratory rats to investigate the effects of microinjections of 10(-13)-10(-4) M bombesin into the solitary tract nucleus on measures of respiration. Bombesin microinjections were found to stimulate respiration, inducing significant increases in the level of pulmonary ventilation, increases in respiratory volume, and increases in the bioelectrical activity of the inspiratory muscles. The most marked respiratory reactions were seen after intermediate peptide doses (10(-10)-10(-7) M). These respiratory effects of bombesin were found to result from its ability to suppress the inspiration-inhibiting Hering-Breuer reflex at the level of the solitary tract nucleus. The fact that ultralow doses of bombesin were active, along with the distribution of endogenous bombesin and its specific receptors in the solitary tract nucleus, and the ability of this peptide to modulate the Hering-Breuer reflex all provide evidence that bombesin is involved in controlling respiration at the level of the dorsal structures of the respiratory center.
在乌拉坦麻醉的成年实验大鼠身上进行了急性实验，以研究向孤束核微量注射10(-13)-10(-4)M蛙皮素对呼吸指标的影响。结果发现，微量注射蛙皮素可刺激呼吸，导致肺通气水平显著增加、呼吸量增加以及吸气肌生物电活动增加。在中等肽剂量（10(-10)-10(-7)M）后观察到最明显的呼吸反应。发现蛙皮素的这些呼吸作用是由于其能够在孤束核水平抑制吸气抑制性黑林-布雷尔反射。超低剂量的蛙皮素具有活性，以及内源性蛙皮素及其特异性受体在孤束核中的分布，还有这种肽调节黑林-布雷尔反射的能力，所有这些都提供了证据，表明蛙皮素参与呼吸中枢背侧结构水平的呼吸控制。
