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生物聚酰胺:重建与整形手术的新事物。

Bio-alcamid: a novelty for reconstructive and cosmetic surgery.

作者信息

Pacini Stefania, Ruggiero Marco, Morucci Gabriele, Cammarota Nazareno, Protopapa Carmelo, Gulisano Massimo

机构信息

Department of Human Anatomy, Histology and Forensic Medicine, University of Firenze, Italy.

出版信息

Ital J Anat Embryol. 2002 Jul-Sep;107(3):209-14.

Abstract

Research for new biocompatible and easily implantable materials continously proposes new molecules and new substances with biological, chemical and physical characteristics more and more adapted to aesthetic and reconstructive surgery. Bio-Alcamid (Polymekon, Italy) is a non reabsorbable polymeric material composed of alkylimide-amide groups. This cosmetic agent has been used for the treatment of 2000 patients by a multicentric trial led by different Hospitals and University in Italy and abroad. Very serious aesthetic defects such as pectus excavatum, Poland Syndrome, postoperative traumas, in addition to common aesthetic defects such as lips, cheek-bone and chin hypovolumetry and relaxing of nasolabial sulcus, have been treated by surgical implant of Bio-Alcamid. Aesthetic results were excellent; tissues felt soft and the implants were uniformly distributed. No migration or dislocation of the implants, no granulomas, no allergic response and no kind of intolerance were observed. Only 12/2000 patients had post-operative complications (Staphylococcus infections) and only 3/12 cases could be directly ascribed to the implanted material. For its characteristics Bio-Alcamid can be considered a novelty in the aesthetic and reconstructive surgery; it is absolutely biocompatible, non toxic, non allergenic, easily injectable and quickly removable. Bio-Alcamid can be defined a sort of "endoprosthetis", perfectly suitable for soft tissue augmentation and for the correction of different tissue deficiences, with a long-term safety and efficiency.

摘要

对新型生物相容性和易于植入材料的研究不断推出具有越来越适合美容和重建手术的生物、化学和物理特性的新分子和新物质。Bio-Alcamid(意大利Polymekon公司)是一种由烷基酰亚胺-酰胺基团组成的不可吸收聚合物材料。这种美容剂已通过意大利国内外不同医院和大学牵头的多中心试验用于治疗2000名患者。除了常见的美容缺陷,如嘴唇、颧骨和下巴容量不足以及鼻唇沟松弛外,非常严重的美容缺陷,如漏斗胸、波兰综合征、术后创伤等,都通过Bio-Alcamid的手术植入进行了治疗。美容效果极佳;组织感觉柔软,植入物分布均匀。未观察到植入物迁移或移位、无肉芽肿、无过敏反应和无任何不耐受情况。2000名患者中只有12例出现术后并发症(葡萄球菌感染),其中只有3例可直接归因于植入材料。因其特性,Bio-Alcamid可被视为美容和重建手术中的一种新型材料;它绝对具有生物相容性、无毒、无过敏、易于注射且可快速取出。Bio-Alcamid可被定义为一种“内置假体”,非常适合软组织填充和纠正不同的组织缺陷,具有长期的安全性和有效性。

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