Finkelstein Alexei V
Institute of Protein Research, Russian Academy of Sciences, 142290, Pushchino, Moscow Region, Russia.
J Biomol Struct Dyn. 2002 Dec;20(3):311-3. doi: 10.1080/07391102.2002.10506846.
A hierarchic scheme of protein folding does not solve the Levinthal paradox since it cannot provide a simultaneous explanation for major features observed for protein folding: (i) folding within non-astronomical time, (ii) independence of the native structure on large variations in the folding rates of given protein under different conditions, and (iii) co-existence, in a visible quantity, of only the native and the unfolded molecules during folding of moderate size (single-domain) proteins. On the contrary, a nucleation mechanism can account for all these major features simultaneously and resolves the Levinthal paradox.
蛋白质折叠的层次结构方案并不能解决莱文索尔悖论，因为它无法同时解释蛋白质折叠所观察到的主要特征：（i）在非天文时间内折叠；（ii）天然结构与给定蛋白质在不同条件下折叠速率的大幅变化无关；（iii）在中等大小（单结构域）蛋白质折叠过程中，仅天然分子和未折叠分子以可观数量共存。相反，成核机制可以同时解释所有这些主要特征，并解决莱文索尔悖论。
