Rooman Marianne, Dehouck Yves, Kwasigroch Jean Marc, Biot Christophe, Gilis Dimitri
Ingénierie Biomoléculaire, Université Libre de Bruxelles, CP 165/64, 50 Avenue Roosevelt, Belgium.
J Biomol Struct Dyn. 2002 Dec;20(3):327-9. doi: 10.1080/07391102.2002.10506850.
We would be tempted to state that there has never been a Levinthal paradox. Indeed, Levinthal raised an interesting problem about protein folding, as he realized that proteins have no time to explore exhaustively their conformational space on the way to their native structure. He did not seem to find this paradoxical and immediately proposed a straightforward solution, which has essentially never been refuted. In other words, Levinthal solved his own paradox.
我们可能会忍不住说，从来就没有过莱文索尔悖论。的确，莱文索尔提出了一个关于蛋白质折叠的有趣问题，因为他意识到蛋白质在形成天然结构的过程中没有时间详尽地探索其构象空间。他似乎并不觉得这有什么矛盾之处，而是立即提出了一个直截了当的解决方案，而这个方案基本上从未被推翻过。换句话说，莱文索尔解决了他自己提出的悖论。
