Grosberg A
Department of Physics, University of Minnesota, Minneapolis 55455, USA.
J Biomol Struct Dyn. 2002 Dec;20(3):317-21. doi: 10.1080/07391102.2002.10506848.
We estimate that the longest protein chain capable of exhaustive sampling of all its conformations within a millisecond is shorter than 15 residues. This reinforces the understanding of Levinthal paradox which emerged in the last decade, namely, that cooperative (all-or-none) character of folding and unfolding transition is indicative of the sequences selected such that reliable folding does not require exhaustive conformation sampling. The opinion is formulated that the discussions of Levinthal paradox should now fly to the new spheres.
我们估计，能够在一毫秒内对其所有构象进行详尽采样的最长蛋白质链短于15个残基。这强化了对过去十年中出现的莱文索尔悖论的理解，即折叠和展开转变的协同（全或无）特征表明所选择的序列使得可靠折叠不需要详尽的构象采样。有人提出，现在对莱文索尔悖论的讨论应该进入新的领域。
