Watters James W, McLeod Howard L
Department of Medicine, The Siteman Cancer Center4, Washington University School of Medicine, 660 S. Euclid Ave-Campus Box 8069, St Louis, Missouri 63110, USA.
Pharmacogenomics. 2002 Nov;3(6):781-90. doi: 10.1517/14622416.3.6.781.
Pharmacogenomics seeks to understand the genetic basis of interindividual differences in drug disposition and effects. Differential drug response is likely to most often be a complex trait, in which multiple genes contribute with varying strengths to the therapeutic phenotype. Due to technical and economic limitations, pharmacogenomic studies in humans are mainly limited to a small number of candidate genes with relatively major influences on drug response. This review discusses the problems involved in mapping genes underlying drug response in humans and highlights the theoretical and applied uses of mouse genetics to address these important issues.
药物基因组学旨在了解个体间药物处置和效应差异的遗传基础。药物反应差异很可能大多是一种复杂性状，其中多个基因以不同强度对治疗表型产生影响。由于技术和经济限制，人类药物基因组学研究主要局限于少数对药物反应有相对较大影响的候选基因。本文综述了人类药物反应相关基因定位中存在的问题，并强调了小鼠遗传学在解决这些重要问题方面的理论和应用价值。
