Watters James W, McLeod Howard L
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
Trends Pharmacol Sci. 2003 Feb;24(2):55-8. doi: 10.1016/S0165-6147(02)00044-5.
Differential drug response is most often likely to be a complex trait, controlled by the combined influences of multiple genes and environmental influences. As a result of theoretical and technical limitations, to date, most clinically useful pharmacogenomic studies in humans have been limited to a small number of candidate genes that have a relatively major impact on drug response. Here, the problems involved in identifying genes that underlie drug response in humans are discussed and the power of mouse genetics as a tool for pharmacogenomic discovery is highlighted.
药物反应差异很可能是一种复杂性状，受多个基因和环境因素的综合影响。由于理论和技术上的限制，迄今为止，人类中大多数具有临床实用性的药物基因组学研究都局限于少数对药物反应有相对较大影响的候选基因。本文讨论了在人类中鉴定药物反应相关基因所涉及的问题，并强调了小鼠遗传学作为药物基因组学发现工具的作用。
