CCR5等位基因变异与哮喘易感性之间关联的进一步支持。

Further support for the association of CCR5 allelic variants with asthma susceptibility.

作者信息

McGinnis R, Child F, Clayton S, Davies S, Lenney W, Illig T, Wjst M, Spurr N, Debouck C, Hajeer A H, Ollier W E R, Strange R, Fryer A A

机构信息

GlaxoSmithKline Pharmaceuticals, Harlow, Essex, UK.

出版信息

Eur J Immunogenet. 2002 Dec;29(6):525-8. doi: 10.1046/j.1365-2370.2002.00357.x.

DOI:10.1046/j.1365-2370.2002.00357.x

PMID:12437612

Abstract

English and German nuclear families containing multiple asthmatic children and asthmatic parents were analysed to retest a recently reported association between resistance to asthma and the delta32 allele of chemokine receptor 5 (CCR5). Analysis of the families by the transmission-disequilibrium test (TDT) revealed a non-significant trend in the English families that provided marginal confirmation of the association (P < 0.125), but no similar trend was observed in the German families. Case-control comparison of delta32 allele and genotype frequencies in asthmatic vs. non-asthmatic parents revealed a significantly lower frequency of delta32 in asthmatic English parents (P < 0.009) and a similar but non-significant trend in German parents (P < 0.265). Taken together, the pattern of results provides confirmation for the previously observed delta32-asthma association and indicates that susceptibility to asthma may be influenced by CCR5 or another gene in chromosomal region 3p21.

摘要

对包含多个哮喘儿童和哮喘父母的英国家庭和德国家庭进行分析，以重新检验最近报道的趋化因子受体5（CCR5）的δ32等位基因与哮喘抗性之间的关联。通过传递不平衡检验（TDT）对这些家庭进行分析，结果显示英国家庭存在不显著的趋势，为该关联提供了边际性的证实（P < 0.125），但德国家庭未观察到类似趋势。对哮喘父母与非哮喘父母的δ32等位基因和基因型频率进行病例对照比较，结果显示哮喘英国家长中δ32的频率显著较低（P < 0.009），德国家长中也有类似但不显著的趋势（P < 0.265）。综合来看，这些结果模式证实了之前观察到的δ32与哮喘的关联，并表明哮喘易感性可能受CCR5或染色体区域3p21中的另一个基因影响。