CCR5基因缺失32与哮喘风险降低的关联。
Association of CCR5 delta32 with reduced risk of asthma.
作者信息
Hall I P, Wheatley A, Christie G, McDougall C, Hubbard R, Helms P J
出版信息
Lancet. 1999 Oct 9;354(9186):1264-5. doi: 10.1016/s0140-6736(99)03425-x.
Abstract
We report that individuals carrying the CCR5 delta32 mutation, a naturally occurring variant of the C-C chemokine receptor 5 (CCR5), are at reduced risk of developing asthma. These data suggest a possible explanation for the high prevalence of this mutation in the general population.
摘要
我们报告称，携带CCR5 delta32突变（C-C趋化因子受体5（CCR5）的一种自然发生的变体）的个体患哮喘的风险降低。这些数据为该突变在普通人群中的高流行率提供了一种可能的解释。
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