Fujii Nobuharu, Ikeda Kazuma, Takahashi Naoto, Kojima Kensuke, Kobayashi Yoshimi, Ashiba Atsuko, Takenaka Katsuto, Fukuda Shunnichi, Shinagawa Katsuji, Ishimaru Fumihiko, Niiya Kenji, Miura Ikuo, Tanimoto Mitsune, Harada Mine
Department of Internal Medicine (II), Okayama University Medical School, Okayama, Japan.
Br J Haematol. 2002 Dec;119(3):716-9. doi: 10.1046/j.1365-2141.2002.03922.x.
We report a patient with hypereosinophilic syndrome (HES), which, 8 years later, transformed into granulocytic sarcoma in the brain and, subsequently, into acute myelocytic leukaemia. Repeated chromosome analyses showed a normal karyotype, until the time of leukaemic transformation when trisomy 8 was confirmed in cells from the bone marrow and cerebrospinal fluid. The combined techniques of May-Grunwald-Giemsa staining and fluorescence in situ hybridization identified trisomy 8 not only in blasts and eosinophils but also in neutrophils and erythroblasts. Our observation suggests that HES is a multilineage myeloproliferative disorder involving precursors of at least the eosinophil, neutrophil and erythroid lineages.
我们报告了一名患有高嗜酸性粒细胞综合征（HES）的患者，8年后该疾病转变为脑部粒细胞肉瘤，随后又转变为急性髓细胞白血病。反复的染色体分析显示核型正常，直至白血病转化时，才在骨髓和脑脊液细胞中证实存在8号染色体三体。May-Grunwald-Giemsa染色和荧光原位杂交联合技术不仅在原始细胞和嗜酸性粒细胞中鉴定出8号染色体三体，在中性粒细胞和早幼红细胞中也发现了该三体。我们的观察表明，HES是一种多谱系骨髓增殖性疾病，至少涉及嗜酸性粒细胞、中性粒细胞和红系谱系的前体细胞。
