Doorduijn J K, van Lom K, Löwenberg B
Department of Haematology, University Hospital Rotterdam, The Netherlands.
Br J Haematol. 1996 Dec;95(3):531-4. doi: 10.1046/j.1365-2141.1996.d01-1931.x.
Eosinophilia of variable duration, and subsequent progression to granulocytic sarcoma and acute myeloid leukaemia, has been infrequently reported in the literature. We report a patient with eosinophilia and normal cytogenetics who, after 24 years, showed transformation to a granulocytic sarcoma of the brain. Haematological counts were normal but the marrow revealed the cytogenetic abnormality trisomy 8 in 25% of mitoses. Subsequently an AML-M2 developed, showing a complex karyotype including the trisomy 8 in all metaphases. FISH analysis combined with cytological examination identified the trisomy 8 in blasts, eosinophils and dysplastic granulocytes only. Thus progressive leukaemic transformation selectively involved the myeloid compartment.
文献中鲜有关于持续时间不一的嗜酸性粒细胞增多症，以及随后进展为粒细胞肉瘤和急性髓系白血病的报道。我们报告了一名患有嗜酸性粒细胞增多症且细胞遗传学正常的患者，24年后该患者转变为脑粒细胞肉瘤。血液学计数正常，但骨髓检查显示25%的有丝分裂中存在细胞遗传学异常8号染色体三体。随后发展为急性髓系白血病M2型，所有中期细胞均显示复杂核型，包括8号染色体三体。荧光原位杂交（FISH）分析结合细胞学检查仅在原始细胞、嗜酸性粒细胞和发育异常的粒细胞中发现8号染色体三体。因此，白血病的进展性转化选择性地累及髓系。
