土耳其一家教学医院中铜绿假单胞菌对抗生素的药敏模式及交叉耐药性
Susceptibility patterns and cross resistances of antibiotics against Pseudomonas aeruginosa in a teaching hospital of Turkey.
作者信息
Gençer Serap, Ak Oznur, Benzonana Nur, Batirel Ayşe, Ozer Serdar
机构信息
Department of Infectious Diseases and Clinical Microbiology, Kartal Dr. Lütfi Kirdar Training and Research Hospital, Istanbul, Turkey.
出版信息
Ann Clin Microbiol Antimicrob. 2002 Oct 9;1:2. doi: 10.1186/1476-0711-1-2.
BACKGROUND
Pseudomonas aeruginosa is the third most common pathogen responsible for nosocomial infections and the prevalence of multiple resistant isolates has been increasing. Ninety-nine clinical isolates were studied in order to assess the current levels of susceptibility and cross-resistances of widely used antipseudomonal antibiotics against P. aeruginosa and to determine some resistance mechanisms by phenotypic methods.
METHODS
MICs of isolates for nine antipseudomonal antibiotics were determined by the E test method.
RESULTS
Thirty-six percent of isolates were resistant to more than one group of antibiotics. The rates of susceptible isolates were ciprofloxacin 75%, amikacin 73%, ceftazidime 65%, meropenem 63%, imipenem 63%, piperacillin/tazobactam 60%, cefoperazone/sulbactam 59%, cefepime 54% and tobramycin 44%. The majority of carbapenem resistant isolates were susceptible to ciprofloxacin and amikacin.
CONCLUSION
Ciprofloxacin seems to be the most active agent against P. aeruginosa followed by amikacin in our unit. The usefulness of combinations of these antibiotics and beta-lactams should be tested in treating multi-drug resistant P. aeruginosa.
背景
铜绿假单胞菌是医院感染的第三大常见病原体，多重耐药菌株的流行率一直在上升。对99株临床分离株进行了研究，以评估广泛使用的抗铜绿假单胞菌抗生素对铜绿假单胞菌的当前敏感性水平和交叉耐药性，并通过表型方法确定一些耐药机制。
方法
采用E试验法测定分离株对9种抗铜绿假单胞菌抗生素的最低抑菌浓度（MIC）。
结果
36%的分离株对一组以上抗生素耐药。敏感分离株的比例分别为：环丙沙星75%、阿米卡星73%、头孢他啶65%、美罗培南63%、亚胺培南63%、哌拉西林/他唑巴坦60%、头孢哌酮/舒巴坦59%、头孢吡肟54%、妥布霉素44%。大多数碳青霉烯类耐药分离株对环丙沙星和阿米卡星敏感。
结论
在我们科室，环丙沙星似乎是抗铜绿假单胞菌活性最强的药物，其次是阿米卡星。这些抗生素与β-内酰胺类药物联合使用治疗多重耐药铜绿假单胞菌感染的有效性应进行测试。
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