Batterham Marijka J, Garsia Roger, Greenop Philippa
Department of Nutrition and Dietetics, Royal Prince Alfred Hospital, Missenden Road, Camperdown, Sydney, NSW 2050, Australia.
Int J STD AIDS. 2002 Nov;13(11):744-7. doi: 10.1258/095646202320753682.
This study was a cross-sectional study of 122 HIV-positive subjects to determine the prevalence and predictors of weight loss in the era of highly active antiretroviral therapy (HAART). Forty per cent reported lipodystrophy, 40% had documented weight loss (mean 6.6 kg). Mean intake 13,400 kJ (118% of estimated requirements calculated using the Harris-Benedict equation). One hundred (82%) were taking antiretroviral therapy. Using forward stepwise logistic regression analysis only viral load (VL) was significantly associated with weight loss when intake, CD4 T-cell count, lipodystrophy, and age were entered into the model with VL (log copies/mL). Every one log increase in HIV VL was associated with an odds of weight loss of 1.58 (P=0.0008). Weight loss is still common in the HAART era. HIV VL was the most significant predictor of weight loss in this sample. Inadequate dietary intake and self-reported lipodystrophy were not related to weight loss in this population.
本研究是一项针对122名HIV阳性受试者的横断面研究，旨在确定高效抗逆转录病毒治疗（HAART）时代体重减轻的患病率及预测因素。40%的受试者报告有脂肪代谢障碍，40%有记录的体重减轻（平均6.6千克）。平均摄入量为13400千焦（按哈里斯-本尼迪克特方程计算为估计需求量的118%）。100名（82%）受试者正在接受抗逆转录病毒治疗。在将摄入量、CD4 T细胞计数、脂肪代谢障碍和年龄与病毒载量（VL，对数拷贝/毫升）纳入模型后，采用向前逐步逻辑回归分析，发现只有病毒载量与体重减轻显著相关。HIV病毒载量每增加一个对数，体重减轻的几率为1.58（P = 0.0008）。在HAART时代，体重减轻仍然很常见。在该样本中，HIV病毒载量是体重减轻的最显著预测因素。在该人群中，饮食摄入不足和自我报告的脂肪代谢障碍与体重减轻无关。
