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恶性疟原虫丝氨酸重复蛋白，单核细胞依赖性抗体介导的寄生虫杀伤作用的新靶点。

Plasmodium falciparum serine repeat protein, a new target of monocyte-dependent antibody-mediated parasite killing.

作者信息

Soe Soe, Singh Subhash, Camus Daniel, Horii Toshihiro, Druilhe Pierre

机构信息

BioMedical Parasitology Unit, Pasteur Institute, 75015 Paris, France.

出版信息

Infect Immun. 2002 Dec;70(12):7182-4. doi: 10.1128/IAI.70.12.7182-7184.2002.

DOI:10.1128/IAI.70.12.7182-7184.2002
PMID:12438408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC133104/
Abstract

Using monoclonal antibodies and human affinity-purified antibodies specific to the Plasmodium falciparum 126-kDa serine-rich protein, SERP, we found that these antibodies have no direct effect upon merozoite invasion at the concentrations tested but can cooperate with blood monocytes to strongly inhibit P. falciparum in vitro growth.

摘要

利用针对恶性疟原虫126千道尔顿富含丝氨酸蛋白（SERP）的单克隆抗体和人亲和纯化抗体，我们发现这些抗体在测试浓度下对裂殖子入侵没有直接影响，但可与血液单核细胞协同作用，在体外强烈抑制恶性疟原虫的生长。

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本文引用的文献

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Natural human immunoglobulin G subclass responses to Plasmodium falciparum serine repeat antigen in Uganda.乌干达人群对恶性疟原虫丝氨酸重复抗原的天然免疫球蛋白G亚类反应
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Antibodies reactive with the N-terminal domain of Plasmodium falciparum serine repeat antigen inhibit cell proliferation by agglutinating merozoites and schizonts.与恶性疟原虫丝氨酸重复抗原N端结构域反应的抗体通过凝集裂殖子和裂殖体抑制细胞增殖。
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The glutamate-rich protein (GLURP) of Plasmodium falciparum is a target for antibody-dependent monocyte-mediated inhibition of parasite growth in vitro.恶性疟原虫的富含谷氨酸蛋白（GLURP）是抗体依赖性单核细胞在体外介导抑制寄生虫生长的靶点。
Infect Immun. 1998 Jan;66(1):11-7. doi: 10.1128/IAI.66.1.11-17.1998.
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Fast immunopurification of small amounts of specific antibodies on peptides bound to ELISA plates.在酶联免疫吸附测定（ELISA）板上结合的肽段上快速免疫纯化少量特异性抗体。
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Merozoite surface protein-3: a malaria protein inducing antibodies that promote Plasmodium falciparum killing by cooperation with blood monocytes.裂殖子表面蛋白-3：一种疟疾蛋白，可诱导抗体，通过与血液单核细胞合作促进恶性疟原虫的杀伤。
Blood. 1994 Sep 1;84(5):1594-602.
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