Translational control in the endoplasmic reticulum stress response.
作者信息
Ron David
机构信息
Skirball Institute of Biomolecular Medicine, Department of Medicine, New York, New York 10016, USA.
出版信息
J Clin Invest. 2002 Nov;110(10):1383-8. doi: 10.1172/JCI16784.
Abstract
摘要
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本文引用的文献
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Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum.内质网生物合成负荷细胞应答中的翻译调控。
Cold Spring Harb Symp Quant Biol. 2001;66:499-508. doi: 10.1101/sqb.2001.66.499.
2
Orchestrating the unfolded protein response in health and disease.调控健康与疾病中的未折叠蛋白反应。
J Clin Invest. 2002 Nov;110(10):1389-98. doi: 10.1172/JCI16886.
3
The unfolded protein response in nutrient sensing and differentiation.营养感知与分化中的未折叠蛋白反应
Nat Rev Mol Cell Biol. 2002 Jun;3(6):411-21. doi: 10.1038/nrm829.
4
The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas.PERK真核起始因子2α激酶是骨骼系统发育、出生后生长以及胰腺功能和生存能力所必需的。
Mol Cell Biol. 2002 Jun;22(11):3864-74. doi: 10.1128/MCB.22.11.3864-3874.2002.
5
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases.聚集体的内在毒性意味着蛋白质错误折叠疾病存在共同机制。
Nature. 2002 Apr 4;416(6880):507-11. doi: 10.1038/416507a.
6
Gene-specific regulation by general translation factors.一般翻译因子的基因特异性调控。
Cell. 2002 Feb 22;108(4):545-56. doi: 10.1016/s0092-8674(02)00642-6.
7
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes.Chop基因的靶向破坏可延缓内质网应激介导的糖尿病。
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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA.肌醇需求酶1（IRE1）通过加工XBP-1信使核糖核酸（mRNA），将内质网负荷与分泌能力联系起来。
Nature. 2002 Jan 3;415(6867):92-6. doi: 10.1038/415092a.
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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.XBP1信使核糖核酸由激活转录因子6诱导产生，并在受到内质网应激时由肌醇需求酶1进行剪接，以产生一种高活性转录因子。
Cell. 2001 Dec 28;107(7):881-91. doi: 10.1016/s0092-8674(01)00611-0.
10
Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency.血红素调节的真核起始因子2α激酶（HRI）是缺铁时红细胞前体翻译调控和存活所必需的。
EMBO J. 2001 Dec 3;20(23):6909-18. doi: 10.1093/emboj/20.23.6909.
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