Bartlett P A, Richardson M P, Duncan J S
MRI Unit, National Society for Epilepsy, Chalfont St Peter, Buckinghamshire, UK.
J Neurol Neurosurg Psychiatry. 2002 Dec;73(6):753-5. doi: 10.1136/jnnp.73.6.753.
To implement and validate the use of coronal dual echo T2 maps for the measurement of T2 relaxation time of the amygdala (AT2) as a rapid and reproducible method for identifying amygdala abnormality.
20 healthy subjects and 25 patients with known hippocampal sclerosis (HS) were studied using a dual echo CSE sequence on a 1.5T MRI GE scanner. The T2 relaxation time of the amygdala was calculated and measured using a previously validated method.
The mean control AT2 was 88.1 ms (SD 2 ms). The coefficient of reliability was good at 6.3% test-retest and 7.4% inter-rater. The upper limit of normal AT2 was 92 ms. AT2 was abnormal ipsilaterally in six, and bilaterally in three, of 20 patients with unilateral HS. Two of five patients with bilateral HS had unilateral abnormal AT2.
Reliable T2 measurements can be obtained in the amygdala, and may be useful in the detection of amygdala abnormality.
实施并验证冠状面双回波T2图谱用于测量杏仁核T2弛豫时间（AT2），作为一种快速且可重复的识别杏仁核异常的方法。
使用1.5T GE磁共振成像扫描仪上的双回波CSE序列，对20名健康受试者和25名已知海马硬化（HS）患者进行研究。采用先前验证的方法计算并测量杏仁核的T2弛豫时间。
对照组AT2的平均值为88.1毫秒（标准差2毫秒）。重测信度系数良好，重测为6.3%，评分者间为7.4%。AT2的正常上限为92毫秒。在20名单侧HS患者中，6例同侧AT2异常，3例双侧异常。5例双侧HS患者中有2例单侧AT2异常。
可在杏仁核中获得可靠的T2测量值，这可能有助于检测杏仁核异常。
