Duncan J S, Bartlett P, Barker G J
MR Unit, National Society for Epilepsy, Institute of Neurology, Bucks, United Kingdom.
AJNR Am J Neuroradiol. 1996 Nov-Dec;17(10):1805-10.
To implement and validate methods for producing calculated coronal T2 maps with complete coverage of the hippocampus and the rest of the brain.
T2 relaxation times were estimated on three occasions for 12 quality assessment test objects with the use of fast spin-echo (FSE) and conventional spin-echo (CSE) sequences. Hippocampal T2 relaxation times were measured in 15 healthy subjects with FSE and CSE sequences. Ten of these subjects were scanned twice with CSE imaging. Twenty-two patients with temporal lobe epilepsy, in whom hippocampal T2 relaxation times were previously estimated by means of a multiecho sequence, were studied with CSE.
CSE data were more reliable than FSE data. Reliability of hippocampal T2 measures on repeated acquisitions was superior for the CSE sequence with echo time 30,120 than for the 30,80 sequence (test-retest reliability, 4.0%; interrater reliability, 4.6%). CSE images were suitable for qualitative reporting, so additional T2-weighted sequences were not required. There was good correlation between these hippocampal T2 data and values obtained on a previously validated multiecho technique, with reliable identification of hippocampal sclerosis.
T2 mapping with CSE 30/120 sequences may be readily applied, produces reliable T2 values in contiguous 5-mm sections, and may be useful in the assessment of the hippocampus and other cerebral structures.
实施并验证用于生成覆盖海马体及大脑其他部位的计算冠状位T2图谱的方法。
使用快速自旋回波（FSE）和传统自旋回波（CSE）序列，对12个质量评估测试对象进行了三次T2弛豫时间估计。使用FSE和CSE序列测量了15名健康受试者的海马体T2弛豫时间。其中10名受试者用CSE成像进行了两次扫描。对22例颞叶癫痫患者进行了CSE研究，这些患者之前通过多回波序列估计了海马体T2弛豫时间。
CSE数据比FSE数据更可靠。回波时间为30、120的CSE序列在重复采集时海马体T2测量的可靠性优于30、80序列（重测可靠性为4.0%；评分者间可靠性为4.6%）。CSE图像适用于定性报告，因此不需要额外的T2加权序列。这些海马体T2数据与先前验证的多回波技术获得的值之间具有良好的相关性，能够可靠地识别海马体硬化。
使用CSE 30/120序列进行T2图谱绘制易于应用，在连续5毫米切片中产生可靠的T2值，可能有助于评估海马体和其他脑结构。
