人微小病毒1型中的末端RNA复制元件
Terminal RNA replication elements in human parechovirus 1.
作者信息
Nateri Abdolrahman S, Hughes Pamela J, Stanway Glyn
机构信息
Department of Biological Sciences, University of Essex, Colchester CO4 3SQ, United Kingdom.
出版信息
J Virol. 2002 Dec;76(24):13116-22. doi: 10.1128/jvi.76.24.13116-13122.2002.
Abstract
To define structural elements critical for RNA replication in human parechovirus 1 (HPeV1), a replicon with chloramphenicol acetyltransferase as a reporter gene and an infectious virus cDNA clone have been used. It was observed that there are cis-acting signals required for HPeV1 replication located within the 5'-terminal 112 nucleotides of the genome and that these include two terminal stem-loops, SL-A and SL-B, together with a pseudoknot element. Significant disruption of any of these structures impaired both RNA replication and virus growth. In view of the similarity in terminal structures to several picornaviruses, such as cardioviruses and hepatoviruses, the insights generated in this work are of wider significance for understanding picornavirus replication.
摘要
为了确定人微小病毒1型（HPeV1）中对RNA复制至关重要的结构元件，已使用氯霉素乙酰转移酶作为报告基因的复制子和感染性病毒cDNA克隆。据观察，HPeV1复制所需的顺式作用信号位于基因组5'端的112个核苷酸内，其中包括两个末端茎环结构，即SL-A和SL-B，以及一个假结元件。这些结构中任何一个的显著破坏都会损害RNA复制和病毒生长。鉴于末端结构与几种小RNA病毒（如心病毒和肝病毒）相似，这项工作中获得的见解对于理解小RNA病毒复制具有更广泛的意义。
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