牛25号染色体与人类7号和16号染色体的比较图谱。

A comparative map of bovine chromosome 25 with human chromosomes 7 and 16.

作者信息

Antoniou E, Gallagher D, Taylor J, Davis S, Womack J, Grosz M

机构信息

University of Missouri, S 140 Animal Sciences Research Center, Columbia, MO 65211, USA.

出版信息

Cytogenet Genome Res. 2002;97(1-2):128-32. doi: 10.1159/000064041.

DOI:10.1159/000064041

PMID:12438751

Abstract

A comparative genome map is necessary for the implementation of comparative positional candidate gene cloning in cattle. We have developed a medium density comparative gene map of bovine chromosome 25 (BTA25). A radiation hybrid (RH) panel was used to map nine microsatellites and nine genes. Eight of the nine comparative loci were also mapped by FISH. These results were combined with data from published articles to create a comprehensive comparative map of BTA25 with human chromosomes 7 (HSA7) and 16 (HSA16). This map should facilitate the cloning of genes of interest on bovine chromosome 25.

摘要

比较基因组图谱对于在牛中实施比较定位候选基因克隆是必要的。我们已经构建了牛25号染色体（BTA25）的中密度比较基因图谱。使用辐射杂种（RH）板对9个微卫星和9个基因进行定位。9个比较基因座中的8个也通过荧光原位杂交（FISH）进行了定位。将这些结果与已发表文章的数据相结合，创建了BTA25与人类7号染色体（HSA7）和16号染色体（HSA16）的综合比较图谱。该图谱应有助于克隆牛25号染色体上感兴趣的基因。