Kim J H, Hwang J-M, Kim H J, Yu Y S
Department of Ophthalmology, College of Medicine, Seoul National University & Clinical Research Institute Seoul National University Hospital, Seoul, Korea.
Eye (Lond). 2002 Nov;16(6):710-4. doi: 10.1038/sj.eye.6700208.
AIMS/PURPOSE: To identify the characteristic ocular findings in Asian children with Down syndrome.
A total of 123 Korean children with Down's syndrome between 6 months and 14 years of age were examined for ocular findings from March 1999 to April 2000. Ocular examinations including visual acuity assessment, slit-lamp biomicroscopy, ocular motility, cycloplegic refraction, and ophthalmoscopy were performed.
The ocular findings in decreasing prevalence were the following: upward slanting of the palpebral fissure (78 patients, 63%), epicanthus (75 patients, 61%), epiblepharon (66 patients, 54%), astigmatism (38 patients, 31%), hyperopia (35 patients, 28%), myopia (31 patients, 25%), strabismus (31 patients, 25%, 18 esotropia and 13 exotropia), nystagmus (27 patients, 22%), nasolacrimal duct obstruction (21 patients, 17%), blepharoconjunctivitis (20 patients, 16%), retinal abnormalities (18 patients, 15%), cataract (four patients, 13%), and glaucoma (one patient, 0.8%). Brushfield spots and keratoconus were not found.
Asian children with Down syndrome demonstrate unreported, high incidence of epiblepharon, the high rate of exotropia, and essentially no notable Brushfield spots, which are in contrast to the ocular findings in Caucasian patients with Down syndrome.
确定亚洲唐氏综合征患儿的特征性眼部表现。
1999年3月至2000年4月，对123名6个月至14岁的韩国唐氏综合征患儿进行眼部检查。检查内容包括视力评估、裂隙灯生物显微镜检查、眼球运动、睫状肌麻痹验光和眼底检查。
眼部表现按患病率递减依次为：睑裂向上倾斜（78例，63%）、内眦赘皮（75例，61%）、睑裂斑（66例，54%）、散光（38例，31%）、远视（35例，28%）、近视（31例，25%）、斜视（31例，25%，内斜视18例，外斜视13例）、眼球震颤（27例，22%）、鼻泪管阻塞（21例，17%）、睑结膜炎（20例，16%）、视网膜异常（18例，15%）、白内障（4例，13%）和青光眼（1例，0.8%）。未发现Brushfield斑和圆锥角膜。
亚洲唐氏综合征患儿睑裂斑的发生率未报告且较高，外斜视发生率高，基本无明显的Brushfield斑，这与白种人唐氏综合征患者的眼部表现不同。
