Gagliardi G M, Gerace G, Martire V, Caruso F, Vocaturo G, De Vuono D, Iacino F, De Napoli N
Unita' Operativa di Nefrologia, Dialisi e Trapianto, Azienda Ospedaliera di Cosenza, Italy.
G Ital Nefrol. 2002 Sep-Oct;19(5):545-51.
The main objective of monitoring vascular access flow in haemodialysis is maintenance of adequate access blood flow (Qac ) to prevent underdialysis and detection of haemodynamically significant stenosis prior to thrombosis.
Recirculation and intra-access pressure were measured to monitor arteriovenous fistulae in a group of haemodialysed patients, for a period of six months. Vascular access blood flow measurements were taken at the first (t0), second (t1) and sixth month (t2) by recirculation measurements using the thermodilution technique (BTM) consistent with Krivitsky's theory. Intra-access pressure measurements were made using the simplified Besarab's method.
No statistically significant differences were noted in recirculation, vascular access blood flow, cardiac output and intra-access measurements during the three periods of the study. Vascular access blood flow was significantly and positively correlated with the arterial blood pressure measured at the same time, but not with the intra-access and venous pressures. Data indicate that mean Qac values = 300 mL/m. and induced recirculation values (Rp) = 45 and = 50 are correlated with angiographic findings of vascular access dysfunction. We observed that patients with mean Qac values between 300 and 650 mL/m had negative angiograms.
We conclude that calculation of access flow by the double recirculation technique is a better and earlier predictor of access dysfunction whereas intra-access pressure measurements are not as useful for this purpose.
血液透析中监测血管通路血流量的主要目的是维持足够的通路血流量(Qac)以防止透析不充分,并在血栓形成之前检测出血流动力学上具有显著意义的狭窄。
对一组血液透析患者的动静脉内瘘进行为期六个月的监测,测量再循环和通路内压力。在第一个月(t0)、第二个月(t1)和第六个月(t2),采用与克里维茨基理论一致的热稀释技术(BTM)通过再循环测量来获取血管通路血流量。通路内压力测量采用简化的贝萨拉布方法。
在研究的三个阶段中,再循环、血管通路血流量、心输出量和通路内测量值均未发现有统计学意义的差异。血管通路血流量与同时测量的动脉血压呈显著正相关,但与通路内压力和静脉压力无关。数据表明,平均Qac值 = 300 mL/m,诱导再循环值(Rp) = 45和 = 50与血管通路功能障碍的血管造影结果相关。我们观察到,平均Qac值在300至650 mL/m之间的患者血管造影结果为阴性。
我们得出结论,通过双再循环技术计算通路血流量是通路功能障碍更好且更早的预测指标,而通路内压力测量在这方面则不太有用。