Yeo C K, Hapizah M N, Khalid B A K, Nazaimoon W M Wan, Khalid Y
Cardiology Unit, Department of Medicine, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur.
Med J Malaysia. 2002 Sep;57(3):298-303.
Diabetes mellitus is an important risk factor for the development of coronary artery disease. The presence of microalbuminuria, which indicates renal involvement in diabetic patients, influences the progression of coronary artery disease. New coronary risk factors such as C-reactive protein (CRP), Lipoprotein a [Lp (a)] and fibrinogen are increasingly being recognized as important cardiovascular prognostic factors. These new coronary risk factors could account for the worse cardiovascular prognosis in diabetic patients with microalbuminuria. Our cross sectional study was to compare the prevalence of elevated CRP and the levels of Lp (a) and fibrinogen between diabetic patients with microalbuminuria and those without microalbuminuria. Diabetic patients with overt coronary artery disease were excluded from the study. A total of 108 patients were recruited of which 57 patients had microalbuminuria and 51 were without microalbuminuria. There was no difference in the number of patients with elevated CRP between these two groups. There were also no significant differences in the mean values of Lp (a) and fibrinogen between diabetic patients with and without microalbuminuria. The inflammatory marker CRP and coagulopathy markers i.e. Lp (a) and fibrinogen seem not to be perturbed in diabetic patients with microalbuminuria.
糖尿病是冠状动脉疾病发生的重要危险因素。微量白蛋白尿的存在表明糖尿病患者存在肾脏受累情况，它会影响冠状动脉疾病的进展。诸如C反应蛋白（CRP）、脂蛋白a [Lp（a）]和纤维蛋白原等新的冠状动脉危险因素越来越被认为是重要的心血管预后因素。这些新的冠状动脉危险因素可能是导致有微量白蛋白尿的糖尿病患者心血管预后较差的原因。我们的横断面研究旨在比较有微量白蛋白尿的糖尿病患者和无微量白蛋白尿的糖尿病患者中CRP升高的患病率以及Lp（a）和纤维蛋白原水平。患有明显冠状动脉疾病的糖尿病患者被排除在研究之外。总共招募了108名患者，其中57名患者有微量白蛋白尿，51名患者无微量白蛋白尿。两组之间CRP升高的患者数量没有差异。有微量白蛋白尿和无微量白蛋白尿的糖尿病患者之间Lp（a）和纤维蛋白原的平均值也没有显著差异。炎症标志物CRP以及凝血异常标志物即Lp（a）和纤维蛋白原在有微量白蛋白尿的糖尿病患者中似乎未受干扰。
