Torgerson J S
Sahlgrenska University Hospital, Göteborg, Schweden.
MMW Fortschr Med. 2002 Oct 3;144(40):24-6.
The Swedish Obese Subjects (SOS) Study was conducted to determine whether obese patients actually can improve their mortality risk by losing weight. After an initial screening study, a total of 6328 subjects were recruited and comprehensively characterized. In the following interventional study, 2010 of the subjects underwent surgery for obesity (gastric banding, gastroplasty, gastric bypass) while 2037 chose a conventional form of treatment, and acted as controls (matched pairs). After 10 years, the controls had gained an average of 1.4 kg in weight. The surgical subjects, in contrast, showed an appreciable and persisting decrease in weight. In comparison with the control group, this group showed a clear decrease in the incidence of cardiovascular risk factors (among others: hypertension, hypertriglyceridemia, diabetes) as well as an improvement in cardiac function parameters and health-related quality of life. On the basis of the present data, however, no definitive pronouncement on the relationship between weight reduction and decrease in overall mortality rate can yet be made.
瑞典肥胖受试者（SOS）研究旨在确定肥胖患者是否真的可以通过减肥来降低死亡风险。经过初步筛查研究，共招募了6328名受试者并对其进行了全面的特征描述。在接下来的干预性研究中，2010名受试者接受了肥胖手术（胃束带术、胃成形术、胃旁路术），而2037名受试者选择了传统治疗方式并作为对照组（配对）。10年后，对照组体重平均增加了1.4千克。相比之下，接受手术的受试者体重出现了明显且持续的下降。与对照组相比，该组心血管危险因素（包括高血压、高甘油三酯血症、糖尿病等）的发生率明显降低，心脏功能参数和健康相关生活质量也有所改善。然而，根据目前的数据，尚无法就体重减轻与总死亡率降低之间的关系做出明确的论断。
