Young Wise
W.M. Keck Center for Collaborative Neuroscience, Rutgers State University of New Jersey, 604 Allison Rd., Piscataway, NJ 08854-8082, USA.
Prog Brain Res. 2002;137:231-55. doi: 10.1016/s0079-6123(02)37019-5.
Most human spinal cord injuries involve contusions of the spinal cord. Many investigators have long used weight-drop contusion animal models to study the pathophysiology and genetic responses of spinal cord injury. All spinal cord injury therapies tested to date in clinical trial were validated in such models. In recent years, the trend has been towards use of rats for spinal cord injury studies. The MASCIS Impactor is a well-standardized rat spinal cord contusion model that produces very consistent graded spinal cord damage that linearly predicts 24-h lesion volumes, 6-week white matter sparing, and locomotor recovery in rats. All aspects of the model, including anesthesia for male and female rats, age rather than body weight criteria, and arterial blood gases were empirically selected to enhance the consistency of injury.
大多数人类脊髓损伤涉及脊髓挫伤。长期以来，许多研究人员一直使用重物坠落挫伤动物模型来研究脊髓损伤的病理生理学和基因反应。迄今为止，在临床试验中测试的所有脊髓损伤治疗方法均在此类模型中得到验证。近年来，趋势是使用大鼠进行脊髓损伤研究。MASCIS撞击器是一种标准化程度很高的大鼠脊髓挫伤模型，它能产生非常一致的分级脊髓损伤，可线性预测大鼠24小时损伤体积、6周白质保留情况和运动恢复情况。该模型的所有方面，包括雄性和雌性大鼠的麻醉、以年龄而非体重为标准以及动脉血气，都是根据经验选择的，以提高损伤的一致性。
