Wang Shuai, Cai Suying, Zhu Zhemin, Zeng Weibo, Hu Shengxuan, Shi Benchao
Department of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Department of Pediatric Orthopedics, Dongguan Maternal and Child Health Hospital, Dongguan, China.
Front Neurol. 2025 Jun 16;16:1573779. doi: 10.3389/fneur.2025.1573779. eCollection 2025.
Spinal cord injury (SCI), with its enormous impact on individuals and society, seriously affects patients' quality of life and is the focus and challenge of current medical research. The selection of appropriate SCI models and the reduction of heterogeneity between models are crucial for basic research on SCI. Although many articles have summarized and compared various SCI models, there are limited descriptions of how to further select the model animals after selecting the type of model, the degree of SCI, the use of anesthesia and analgesia, experience with modeling techniques, preoperative and postoperative care, management of common complications, sample collection, and evaluation of the spinal cord after injury. This paper aims to provide a practical guide for researchers who need to construct SCI models by combining the experimental experience of our research team in modeling and other related research literature. These guidelines will promote the standardization of SCI models, thus providing a solid foundation for in-depth research on SCI and the development of therapeutic strategies.
脊髓损伤（SCI）对个人和社会影响巨大，严重影响患者生活质量，是当前医学研究的重点和挑战。选择合适的SCI模型以及减少模型间的异质性对于SCI的基础研究至关重要。尽管许多文章已对各种SCI模型进行了总结和比较，但在选择模型类型、SCI程度、麻醉和镇痛的使用、建模技术经验、术前和术后护理、常见并发症的处理、样本采集以及损伤后脊髓评估后，如何进一步选择模型动物的描述有限。本文旨在结合我们研究团队的建模实验经验和其他相关研究文献，为需要构建SCI模型的研究人员提供实用指南。这些指南将促进SCI模型的标准化，从而为深入研究SCI和制定治疗策略奠定坚实基础。
