Lotz J C, Hsieh A H, Walsh A L, Palmer E I, Chin J R
Orthopaedic Bioengineering Laboratory, University of California, San Francisco 94143-0514, USA.
Biochem Soc Trans. 2002 Nov;30(Pt 6):853-8. doi: 10.1042/bst0300853.
Intervertebral disc degeneration has been linked in humans to extreme spinal loading regimens. However, mechanisms by which spinal force influences disc cellularity, morphology and consequently biomechanical function are unclear. To gain insight into mechanobiological interactions within the disc, we developed an in vivo murine tail-compression model. Results from this model demonstrate how deviations in spinal stress induce a cycle of altered cell function and morphology as the disc remodels to a new homoeostatic configuration.
在人类中，椎间盘退变与极端的脊柱负荷方案有关。然而，脊柱力影响椎间盘细胞数量、形态以及生物力学功能的机制尚不清楚。为了深入了解椎间盘内的机械生物学相互作用，我们开发了一种体内小鼠尾部压缩模型。该模型的结果表明，随着椎间盘重塑为新的稳态结构，脊柱应力的偏差如何引发细胞功能和形态改变的循环。
