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[实验性甲状腺素血症和甲状腺功能减退大鼠血清中脂蛋白、胆固醇、甘油三酯、游离脂肪酸和游离甘油的行为]

[The behavior of lipoproteins, cholesterol, triglycerides, free fatty acids and free glycerol in serum of rats with experimental hyperthyroxinemia and hypothyreosis].

作者信息

Hübner G, Renner K, Rauer G

出版信息

Endokrinologie. 1976 Mar;67(1):60-6.

PMID:1244201
Abstract

In hyperthyroxinemic and hypothyreotic rats the lipoprotein level in serum was investigated using agarosegel-electrophoresis and changes in serum level of cholesterol, triglycerides, free fatty acids and glycerol were determined. In hyperthyroxinemic animals the beta-lipoproteins were found in the same level as the control animals, while the prae-beta-fraction was significantly elevated and the alpha-lipoproteins lowered. The cholesterol was significantly reduced, the triglycerides and the glycerol significantly increased. The free fatty acids were slightly elevated. In hypothyreotic animals the beta-and prae-beta-fraction of lipoproteins was significantly elevated. The alpha-lipoproteins were found diminished. Cholesterol and triglyceride values were also significantly increased. The levels of free fatty acids and glycerol did not differ in both groups of animals.

摘要

在甲状腺素过多和甲状腺功能减退的大鼠中,采用琼脂糖凝胶电泳研究血清脂蛋白水平,并测定血清胆固醇、甘油三酯、游离脂肪酸和甘油水平的变化。在甲状腺素过多的动物中,发现β-脂蛋白水平与对照动物相同,而前β-组分显著升高,α-脂蛋白降低。胆固醇显著降低,甘油三酯和甘油显著升高。游离脂肪酸略有升高。在甲状腺功能减退的动物中,脂蛋白的β-和前β-组分显著升高。发现α-脂蛋白减少。胆固醇和甘油三酯值也显著增加。两组动物的游离脂肪酸和甘油水平没有差异。

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