多功能钯催化。2. 串联卤代烯丙基化反应，随后进行瓦克-津治氧化反应或索尼加什ira交叉偶联反应。

Multifunctional palladium catalysis. 2. Tandem haloallylation followed by Wacker-Tsuji oxidation or sonogashira cross-coupling.

作者信息

Thadani Avinash N, Rawal Viresh H

机构信息

Department of Chemistry, The University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, USA.

出版信息

Org Lett. 2002 Nov 28;4(24):4321-3. doi: 10.1021/ol0269603.

DOI:10.1021/ol0269603

PMID:12443088

Abstract

[reaction: see text] Multifunctional palladium catalysis is utilized in the one-pot stereocontrolled synthesis of tetrasubstituted methyl ketones and enynes. The homogeneous palladium dihalide catalyst utilized for the bromo-/chloroallylation of alkynes is reused in situ for subsequent Wacker-Tsuji oxidation or Sonogashira cross-coupling.

摘要

[反应：见正文] 多功能钯催化用于四取代甲基酮和烯炔的一锅法立体控制合成。用于炔烃的溴/氯烯丙基化反应的均相二卤化钯催化剂可原位再用于后续的瓦克-津二反应氧化或 Sonogashira 交叉偶联反应。