Nitrite-mediated decarboxylative conjugation of caffeic acid with glutathione under mildly acidic conditions.
作者信息
Panzella Lucia, Napolitano Alessandra, d'Ischia Marco
机构信息
Department of Organic Chemistry and Biochemistry, University of Naples 'Federico II', Via Cinthia 4, Italy.
出版信息
Bioorg Med Chem Lett. 2002 Dec 16;12(24):3547-50. doi: 10.1016/s0960-894x(02)00795-3.
Abstract
In acetate buffer, pH 4, at room temperature, nitrite ions can mediate an unusual decarboxylative conjugation of caffeic acid with glutathione leading to novel isomeric 2-(3,4-dihydroxyphenyl)-2-S-glutathionylacetaldehyde oximes. These results hint at a possible role of endogenous and/or dietary glutathione in the mechanisms by which caffeic acid can affect the burden of carcinogenic N-nitroso compounds in the digestive tract.
摘要
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