Antimicrobial resveratrol tetramers from the stem bark of Vatica oblongifoliassp. oblongifolia.

作者信息

Zgoda-Pols Joanna R, Freyer Alan J, Killmer Lew B, Porter John R

机构信息

Graduate Program in Pharmacognosy, Department of Chemistry and Biochemistry, and Department of Biological Sciences, University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, Pennsylvania 19104-4495, USA.

出版信息

J Nat Prod. 2002 Nov;65(11):1554-9. doi: 10.1021/np020198w.

DOI:10.1021/np020198w

PMID:12444676

Abstract

Two new resveratrol tetramers, hopeaphenol A (1) and isohopeaphenol A (2), along with the known vaticaphenol A (3), were isolated from the stem bark of Vatica oblongifolia ssp. oblongifolia through bioassay-guided fractionation. The structures and their relative stereochemistry were determined by spectroscopic techniques. Compounds 1 and 3 demonstrated moderate activity against methicillin-resistant Staphylococcus aureus and Mycobacterium smegmatis.

摘要