Lqbal J, Sher A, Hira P R, Al-Aniezi A
Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait.
Clin Microbiol Infect. 2002 Nov;8(11):734-8. doi: 10.1046/j.1469-0691.2002.00451.x.
To detect the incidence of drug-resistant Plasmodium falciparum malaria infection in immigrants and travellers in non-endemic Kuwait.
Over a period of 3 years, July 1995 to September 1998, 1352 malaria patients were enrolled in the study. Of these, 1293 were immigrants from countries where malaria is endemic and 59 were non-immune travellers with a recent history of travel to these countries. The in vitro drug sensitivity was determined in 892 patients.
In all, 892 of 1352 (66.0%) P. falciparum isolates were successfully cultured in vitro for drug sensitivity and 419 (47.0%) isolates showed in vitro resistance to chloroquine or mefloquine. Fifty-six (13.4%) isolates were resistant to both drugs. Chloroquine resistance was observed in > 70% of the isolates from Africa and India followed by Pakistan (39.9%) and Bangladesh (35.9%). The resistance to mefloquine ranged from 26.2% in isolates from Sri Lanka to 47.5% in isolates from African countries.
The study highlights the important trend in drug resistance in P. falciparum malaria in immigrants from south-east Asian and African countries.
检测科威特非疟疾流行区移民和旅行者中耐氯喹恶性疟原虫感染的发生率。
在1995年7月至1998年9月的3年期间，1352例疟疾患者纳入本研究。其中，1293例为来自疟疾流行国家的移民，59例为近期去过这些国家的无免疫力旅行者。对892例患者进行了体外药物敏感性测定。
1352例恶性疟原虫分离株中，892例（66.0%）成功进行体外培养以测定药物敏感性，419例（47.0%）分离株显示对氯喹或甲氟喹有体外耐药性。56例（13.4%）分离株对两种药物均耐药。来自非洲和印度的分离株中，>70%观察到氯喹耐药，其次是巴基斯坦（39.9%）和孟加拉国（35.9%）。对甲氟喹的耐药率从来自斯里兰卡的分离株的26.2%到来自非洲国家的分离株的47.5%不等。
本研究突出了东南亚和非洲国家移民中恶性疟原虫疟疾耐药性的重要趋势。
