Basco L K, Ringwald P, Simon F, Doury J C, Le Bras J
Centre National de Référence de la Chimiosensibilité du Paludisme, Hôpital Bichat-Claude Bernard, Paris, France.
Trop Med Parasitol. 1993 Jun;44(2):111-2.
The evolution of in vitro chloroquine susceptibility of clinical isolates of Plasmodium falciparum obtained from travellers returning to France was studied between 1986 and 1991 using the isotopic semi-microtest. Based on the analysis of 1,147 interpretable tests on isolates originating from Central and West Africa, the study showed that the proportion of chloroquine-resistant falciparum malaria remained stable between 1986 and 1988 and has diminished between 1989 and 1991. The diminution of chloroquine-resistant imported malaria may be associated, at least in part, with a better compliance of French travellers with the recommendation to use either mefloquine or a combination of chloroquine and proguanil since 1989 and an increasing proportion of African immigrants who tend to neglect regular chemoprophylaxis during the visit to their countries. The reason for the stabilisation of chloroquine resistance is unknown, and this phenomenon may be temporary, necessitating a continuous surveillance of drug susceptibility.
1986年至1991年期间，采用同位素半微量试验研究了从返回法国的旅行者身上分离出的恶性疟原虫临床分离株的体外氯喹敏感性演变情况。基于对1147份源自中非和西非分离株的可解释试验分析，该研究表明，耐氯喹恶性疟的比例在1986年至1988年间保持稳定，而在1989年至1991年间有所下降。输入性耐氯喹疟疾的减少至少部分可能与自1989年以来法国旅行者更好地遵守使用甲氟喹或氯喹与氯胍组合的建议有关，以及越来越多的非洲移民在回国访问期间往往忽视定期化学预防有关。氯喹耐药性稳定的原因尚不清楚，这种现象可能是暂时的，因此有必要持续监测药物敏感性。
