Maden Malcolm
MRC Centre for Developmental Neurobiology, King's College London, 4th floor New Hunt's House, Guy's Campus, London Bridge, SE1 1UL, London, UK.
Curr Biol. 2002 Nov 19;12(22):R773-5. doi: 10.1016/s0960-9822(02)01290-3.
In the regenerating amphibian limb, positional information has traditionally been considered in terms of short-range cell-cell interactions, not long-range diffusion gradients. A molecule discovered in a differential screen of regenerating limbs turns out to be precisely such a cell surface component, the newt ortholog of mouse CD59.