Gliemroth Jan, Bahlmann Ludger, Klaus Stefan, Klöhn Anke, Arnold Hans
Department of Neurosurgery, Medical University of Lubeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
Clin Neurol Neurosurg. 2002 Dec;105(1):27-31. doi: 10.1016/s0303-8467(02)00088-4.
As part of invasive neuromonitoring, long-time microdialysis was performed in a 32-year-old patient suffering from meningoencephalitis. Cerebral magnetic resonance imaging (MRI) revealed marked global brain oedema. An intracranial pressure (ICP) probe, brain tissue oxygen pressure measurement (pTiO(2)), and intraparenchymal microdialysis were used for intensive neuromonitoring. Despite high ICP, only intensive care therapy was applied for 16 days using deep propofol sedation, hyperventilation, and intermittent mannitol therapy. One year later, the condition of the patient was excellent. Intracerebral microdialysis with bedside measuring of lactate, pyruvate, glycerol, glucose, and glutamate is a useful additional tool for the monitoring of ICP management.
作为侵入性神经监测的一部分，对一名患有脑膜脑炎的32岁患者进行了长时间的微透析。脑磁共振成像（MRI）显示明显的全脑水肿。使用颅内压（ICP）探头、脑组织氧分压测量（pTiO₂）和脑实质内微透析进行强化神经监测。尽管颅内压很高，但仅采用深度丙泊酚镇静、过度通气和间歇性甘露醇治疗进行了16天的重症监护治疗。一年后，患者状况良好。床边测量乳酸、丙酮酸、甘油、葡萄糖和谷氨酸的脑内微透析是监测颅内压管理的一种有用的辅助工具。
