老年沙鼠迷路中钙结合蛋白和钙视网膜蛋白表达降低。

Decreased expression of calretinin and calbindin in the labyrinth of old gerbils.

作者信息

Kevetter Golda Anne, Leonard Robert B

机构信息

Department of Otolaryngology, University of Texas Medical Branch, Galveston, TX 77555-1063, USA.

出版信息

Brain Res. 2002 Dec 13;957(2):362-5. doi: 10.1016/s0006-8993(02)03668-5.

DOI:10.1016/s0006-8993(02)03668-5

PMID:12445979

Abstract

Calretinin and calbindin staining were compared in the vestibular periphery of old (35-48 months) and young (4-12 months) animals. Both stain calyx-only afferents; calbindin stains additional terminals in the apex [Brain Res. 928 (2002) 8-17]. In six of seven pairs of animals, calretinin and calbindin staining was diminished or absent in the old animals. These changes suggest that a reduction in certain calcium-binding proteins may be a characteristic of aging animals.

摘要

对老年（35 - 48个月）和幼年（4 - 12个月）动物的前庭外周组织中的钙视网膜蛋白和钙结合蛋白染色进行了比较。两者均对仅支配杯状末梢的传入神经进行染色；钙结合蛋白还对顶部的其他终末进行染色[《脑研究》928（2002年）8 - 17]。在七对动物中的六对中，老年动物的钙视网膜蛋白和钙结合蛋白染色减少或缺失。这些变化表明某些钙结合蛋白的减少可能是衰老动物的一个特征。