Kang H J, Ansbacher R, Hammoud M M
Division of Reproduction Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, MI, USA.
Int J Gynaecol Obstet. 2002 Dec;79(3):195-207. doi: 10.1016/s0020-7292(02)00297-7.
To review the clinical evidence available for the treatment of menopausal symptoms with alternative and complementary medicine.
The MEDLINE, PREMEDLINE and COCHRANE electronic databases for the years 1980-2002 were searched for articles concerning soy products, black cohosh, dong quai, acupuncture, ginseng and evening primrose oil. Studies pertaining to menopausal vasomotor symptoms, lipid profiles and bone mineral densities of postmenopausal women were included. The data from clinical trials were reviewed.
Soy isoflavones slightly decrease total cholesterol and LDL levels. The clinical significance of this small change is yet to be determined. The synthetic isoflavone derivative ipriflavone increases bone mineral density in healthy peri- and postmenopausal women with moderate bone mineral densities. Although earlier reports have claimed that soy is beneficial for the improvement of vasomotor symptoms, recent data do not support this claim. There are insufficient data on the other alternative therapies for treating menopausal symptoms at this time.
Alternative and complementary medicine may play a role in the management of menopause, however, well-designed large studies are still needed.
回顾可用于治疗更年期症状的替代医学和补充医学的临床证据。
检索1980年至2002年的MEDLINE、PREMEDLINE和COCHRANE电子数据库，查找有关大豆制品、黑升麻、当归、针灸、人参和月见草油的文章。纳入有关绝经后妇女更年期血管舒缩症状、血脂谱和骨矿物质密度的研究。对临床试验数据进行了回顾。
大豆异黄酮可轻微降低总胆固醇和低密度脂蛋白水平。这一微小变化的临床意义尚待确定。合成异黄酮衍生物依普黄酮可增加骨矿物质密度中等的健康围绝经期和绝经后妇女的骨矿物质密度。尽管早期报告称大豆有益于改善血管舒缩症状，但近期数据并不支持这一说法。目前关于其他替代疗法治疗更年期症状的数据不足。
替代医学和补充医学可能在更年期管理中发挥作用，然而，仍需要设计良好的大型研究。
