Fukada Y, Amemiya A, Kohno K, Sunami R, Kobayashi Y, Hoshi K
Department of Obstetrics and Gynecology, Yamanashi Medical University, Yamanashi, Japan.
Int J Gynaecol Obstet. 2002 Dec;79(3):225-8. doi: 10.1016/s0020-7292(02)00251-5.
This study was designed to correlate fetuses in a normal prenatal population who exhibited transient nuchal translucency (NT) with both prenatal course and pregnancy outcome.
The fetuses with abnormal NT were followed by ultrasonography at 1-2-week intervals during their prenatal course. Fetuses with NT who exhibited no detectable congenital malformations were defined as the NTO group; fetuses with abnormal NT and structural malformations but no chromosomal abnormalities were placed in the SM group; and fetuses with abnormal NT, structural malformations, and chromosomal abnormalities were categorized as the CA group. The groups were compared by: maternal age, weeks of gestation by ultrasound and the NT value at the initial exam, the maximum NT value, and the duration of abnormal NT.
During the study period, 92 fetuses with abnormal NT were found, monochorionic twins excluded. Of the 92 fetuses, 80 were in the NTO group, 10 were in the SM group, and two were in the CA group. The maternal age and the gestational weeks at the initial diagnosis were not significantly different in the NTO and the SM groups. However, the NT value at the initial diagnosis, maximum NT value, and the duration of abnormal NT were significantly greater in the SM group than those values in the NTO group.
Fetuses with transient nuchal translucency commonly had structural malformations, particularly fetuses with significant and large persistent NT.
本研究旨在将正常产前人群中出现短暂颈部半透明带（NT）的胎儿与产前过程及妊娠结局相关联。
在产前过程中，对NT异常的胎儿每隔1 - 2周进行超声检查。NT异常但未检测到先天性畸形的胎儿被定义为NTO组；NT异常且有结构畸形但无染色体异常的胎儿被归入SM组；NT异常、有结构畸形且有染色体异常的胎儿被归类为CA组。通过以下方面对各组进行比较：产妇年龄、超声检查的孕周、初次检查时的NT值、最大NT值以及NT异常持续时间。
在研究期间，共发现92例NT异常的胎儿，不包括单绒毛膜双胎。在这92例胎儿中，80例属于NTO组，10例属于SM组，2例属于CA组。NTO组和SM组的产妇年龄及初次诊断时的孕周无显著差异。然而，SM组初次诊断时的NT值、最大NT值以及NT异常持续时间均显著高于NTO组。
出现短暂颈部半透明带的胎儿通常存在结构畸形，尤其是NT显著且持续时间长的胎儿。
