Fukada Y, Yasumizu T, Takizawa M, Amemiya A, Hoshi K
Department of Obstetrics and Gynecology, Yamanashi Medical University, Japan.
Acta Obstet Gynecol Scand. 1997 Nov;76(10):913-6. doi: 10.3109/00016349709034901.
The purpose of this study was to evaluate the prognosis of fetuses with transient nuchal translucency before 15 weeks of gestation.
A nuchal translucency's measurement of > or = 5 mm was considered abnormal. In the period from 1994 to 1995, twelve fetuses were diagnosed at our institution with nuchal translucency. The fetuses all underwent karyotyping and a complete ultrasonographic search for any associated anomalies and a resolution of nuchal translucency at 1-2 week gestational age intervals.
Five cases ('Transient NT') demonstrated transient nuchal translucency. Seven cases ('Persistent NT') demonstrated persistent nuchal translucency. The 984 cases with no or less than 5 mm of nuchal translucency (control group) gave birth at the same time. The mean initial week of diagnosis was 12.0 +/- 1.6 weeks in 'Transient NT', and 13.6 +/- 1.8 weeks in 'Persistent NT'. The mean maternal age was 30.8 +/- 6.3 years old in 'Transient NT', 28.9 +/- 3.0 years old in 'Persistent NT', and 30.5 +/- 43 years old in the control group. Abnormal karyotypes were detected in one case in 'Transient NT', and in four cases in 'Persistent NT'. Structural malformations were detected in two cases (40%) in 'Transient NT', seven cases (100%) in 'Persistent NT', and 30 cases (3.0%) in the control group.
Regardless of the spontaneous resolution of abnormal nuchal translucency, there was a high association with both karyotypical and structural abnormalities, and the prognosis of such cases was generally poor, especially persistent NT's prognosis.
本研究旨在评估妊娠15周前出现短暂颈部半透明带的胎儿的预后情况。
颈部半透明带测量值≥5mm被视为异常。在1994年至1995年期间，我院诊断出12例有颈部半透明带的胎儿。所有胎儿均进行了染色体核型分析，并进行了全面的超声检查以寻找任何相关异常情况，且在妊娠1至2周的间隔期对颈部半透明带情况进行复查。
5例（“短暂性颈部半透明带”）表现为短暂性颈部半透明带。7例（“持续性颈部半透明带”）表现为持续性颈部半透明带。984例颈部半透明带无或小于5mm的病例（对照组）同期分娩。“短暂性颈部半透明带”组诊断的平均起始孕周为12.0±1.6周，“持续性颈部半透明带”组为13.6±1.8周。“短暂性颈部半透明带”组孕妇平均年龄为30.8±6.3岁，“持续性颈部半透明带”组为28.9±3.0岁，对照组为30.5±4.3岁。“短暂性颈部半透明带”组有1例检测到异常核型，“持续性颈部半透明带”组有4例。“短暂性颈部半透明带”组有2例（40%）检测到结构畸形，“持续性颈部半透明带”组有7例（100%），对照组有30例（3.0%）。
无论异常颈部半透明带是否自发消退，其与染色体和结构异常均高度相关，此类病例的预后通常较差，尤其是持续性颈部半透明带的预后。
