Tekotte Hildegard, Davis Ilan
Wellcome Trust Centre for Cell Biology, ICMB, King's Buildings, The University of Edinburgh, Mayfield Road, EH9 3JR, Edinburgh, UK.
Trends Genet. 2002 Dec;18(12):636-42. doi: 10.1016/s0168-9525(02)02819-6.
Intracellular mRNA localization is a common mechanism of post-transcriptional regulation of gene expression. In a wide range of organisms, mRNA localization coupled with translational regulation target the proteins to their site of function. Here, we describe recent exciting evidence that some mRNAs are transported as particles along the cytoskeleton by the molecular motors dynein, kinesin or myosin. We discuss the key questions of how localized mRNAs might be linked to motors and what determines their cytoplasmic destinations.
细胞内mRNA定位是基因表达转录后调控的一种常见机制。在多种生物体中，mRNA定位与翻译调控相结合，将蛋白质靶向运输到其功能位点。在这里，我们描述了一些最新的令人兴奋的证据，即一些mRNA作为颗粒，通过分子马达动力蛋白、驱动蛋白或肌球蛋白沿着细胞骨架进行运输。我们讨论了一些关键问题，如定位的mRNA如何与马达相连，以及是什么决定了它们在细胞质中的目的地。
