The sensitivity and specificity of 99mTc-sulfur colloid liver imaging in diffuse hepatocellular disease.

The sensitivity and specificity of 99mTc-sulfur colloid liver-spleen imaging in diffuse hepatocellular disease and the significance of image patterns found in these diseases are presented. By visually quantifying the image alterations found in biopsy-proven cases of diffuse hepatocellular disease and analyzing the correlation between the histological diagnosis and the quantified image alteration (individually and by groups), the 99mTc-sulfur colloid liver-spleen image was found to be highly sensitive (83%). Relative discriminatory values were derived for each image finding and a specific image pattern was found in cirrhosis.