Wingard John R, Vogelsang Georgia B, Deeg H Joachim
University of Florida, HSC, College of Medicine, Gainesville 32610, USA.
Hematology Am Soc Hematol Educ Program. 2002:422-44. doi: 10.1182/asheducation-2002.1.422.
With increasing hematopoietic stem cell transplant (HSCT) activity and improvement in outcomes, there are many thousands of HSCT survivors currently being followed by non-transplant clinicians for their healthcare. Several types of late sequelae from HSCT have been noted, and awareness of these complications is important in minimizing late morbidity and mortality. Late effects can include toxicities from the treatment regimen, infections from immunodeficiency, endocrine disturbances, growth impairment, psychosocial adjustment disorders, second malignancies, and chronic graft-versus-host disease (GVHD). A variety of risk factors for these complications have been noted. The clinician should be alert to the potential for these health issues. Preventive and treatment strategies can minimize morbidity from these problems and optimize outcomes.
随着造血干细胞移植（HSCT）活动的增加以及治疗效果的改善，目前有成千上万的HSCT幸存者由非移植临床医生进行医疗随访。HSCT的几种晚期后遗症已被注意到，了解这些并发症对于将晚期发病率和死亡率降至最低很重要。晚期影响可包括治疗方案的毒性、免疫缺陷引起的感染、内分泌紊乱、生长障碍、心理社会适应障碍、第二原发恶性肿瘤以及慢性移植物抗宿主病（GVHD）。已经注意到这些并发症的多种风险因素。临床医生应警惕这些健康问题的可能性。预防和治疗策略可以将这些问题导致的发病率降至最低并优化治疗效果。
