HIV-1 C亚型Gag特异性T细胞反应的稳定模式与埃塞俄比亚HIV感染者CD4 T细胞缓慢下降速率相符。

Stable pattern of HIV-1 subtype C Gag-specific T-cell responses coincides with slow rate of CD4 T-cell decline in HIV-infected Ethiopians.

作者信息

Tsegaye Aster, Ran Leonie, Wolday Dawit, Petros Beyene, Nanlohy Nening M, Meles Hailu, Girma Mulu, Hailu Ermias, Borghans José, Miedema Frank, van Baarle Debbie

机构信息

Ethio-Netherlands AIDS Research Project, Ethiopian Health and Nutrition Research Institute, PO Box 1242, Addis Ababa, Ethiopia.

出版信息

AIDS. 2007 Jan 30;21(3):369-72. doi: 10.1097/QAD.0b013e32801222e3.

DOI:10.1097/QAD.0b013e32801222e3

PMID:17255746

Abstract

We studied HIV-1 clade C Gag-specific T-cell responses in five HIV-infected Ethiopians with a relatively slow (< 15 cells/microl per year) and five with a fast (> 45 cells/microl per year) CD4 T-cell decline longitudinally. Six study subjects had T-cell responses directed to one or more HIV-1 Gag peptides. The persistence of strong and broad anti-Gag cytotoxic T-lymphocyte responses was associated with a slow rate of CD4 T-cell decline and with human leukocyte antigen alleles from the B27 supertype.

摘要

我们纵向研究了5名HIV感染的埃塞俄比亚人（其CD4 T细胞以相对缓慢的速度下降，即每年<15个细胞/微升）和5名CD4 T细胞快速下降（每年>45个细胞/微升）的HIV-1 C亚型Gag特异性T细胞反应。6名研究对象具有针对一种或多种HIV-1 Gag肽的T细胞反应。强烈且广泛的抗Gag细胞毒性T淋巴细胞反应的持续存在与CD4 T细胞缓慢下降的速率以及B27超型的人类白细胞抗原等位基因有关。