Maluf Eliane M C P, Pasquini Ricardo, Eluf Jose N, Kelly Judith, Kaufman David W
Bone Marrow Transplantation Center, Faculty of Medicine, Federal University of Parana, Curitiba, Brazil.
Am J Hematol. 2002 Dec;71(4):268-74. doi: 10.1002/ajh.10232.
This study is the first large-scale epidemiological investigation of acquired aplastic anemia (AAA) in South America. The objective was to estimate the incidence and to identify risk factors for AAA in Brazil. A national case-control study was conducted to investigate the risk factors for the disease. One hundred twenty-five cases and 129 controls were included. Multiple logistic regression was used in the estimation of odds ratios (OR) to control confounding. The size of Brazil made it unfeasible to estimate the incidence of AAA in the whole country, and we limited the calculation to the state of Parana. The annual incidence of AAA in Parana was 2.4 cases/10(6) inhabitants. There was no positive association between chloramphenicol use and AAA (OR 0.4; 95% CI: 0.1-2.9). The OR of AAA associated with household pesticides that include organophosphates in their composition was 2.7 (1.0-8.4). The OR for the usage of unspecified thinner and/or acetone for at least 7 days was 3.0 (1.2-7.3). Cases of AAA in Brazil seem to be associated with some factors traditionally related to this disease, such as certain solvents and the incidence is similar to what has been reported from Europe.
本研究是南美洲首次针对获得性再生障碍性贫血（AAA）的大规模流行病学调查。目的是估计巴西AAA的发病率并确定其危险因素。开展了一项全国性病例对照研究以调查该疾病的危险因素。纳入了125例病例和129例对照。在估计比值比（OR）时采用多元逻辑回归以控制混杂因素。由于巴西幅员辽阔，估计全国范围内AAA的发病率不可行，因此我们将计算范围限定在巴拉那州。巴拉那州AAA的年发病率为2.4例/10⁶居民。氯霉素使用与AAA之间无正相关（OR 0.4；95%可信区间：0.1 - 2.9）。成分中包含有机磷酸盐的家用杀虫剂与AAA相关的OR为2.7（1.0 - 8.4）。使用未指明的稀释剂和/或丙酮至少7天的OR为3.0（1.2 - 7.3）。巴西的AAA病例似乎与一些该疾病的传统相关因素有关，如某些溶剂，且发病率与欧洲报道的相似。
