Ternesten-Hasséus Ewa, Bende Mats, Millqvist Eva
Asthma and Allergy Research Group, Department of Respiratory Medicine and Allergy, Sahlgrenska Academy, Göteborg University, Sweden.
J Occup Environ Med. 2002 Nov;44(11):1012-7. doi: 10.1097/00043764-200211000-00006.
Multiple chemical sensitivity (MCS) is characterized by chemically induced symptoms from multiple organ systems. No consistent physical findings or laboratory abnormalities have been determined for the associated symptoms. Twelve patients with chemically induced airway symptoms, who satisfied Cullen's criteria for MCS, were provoked double-blind, randomized with saline and three increments of inhaled capsaicin. The recordings were compared with those of a control group of healthy individuals. The results found that the patients coughed more than the control subjects at each dose of capsaicin (P < 0.05 for 0.4 mumol/L capsaicin and P < 0.005 for 2 mumol/L and 10 mumol/L). The capsaicin provocation also induced significantly more symptoms in patients with MCS. We conclude that airway sensory reactivity is increased in patients with MCS, a finding which suggests that neurogenic factors may be of importance in this condition.
多重化学物质敏感症（MCS）的特征是多个器官系统出现化学物质诱发的症状。尚未确定与这些相关症状一致的体格检查结果或实验室异常情况。12名有化学物质诱发气道症状且符合卡伦MCS标准的患者，在双盲、随机条件下，分别吸入生理盐水和三种递增剂量的辣椒素。将记录结果与一组健康个体的对照组进行比较。结果发现，在每剂辣椒素作用下，患者咳嗽次数均多于对照受试者（0.4微摩尔/升辣椒素时P<0.05，2微摩尔/升和10微摩尔/升时P<0.005）。辣椒素激发试验在MCS患者中也诱发了明显更多的症状。我们得出结论，MCS患者的气道感觉反应性增强，这一发现表明神经源性因素在这种病症中可能很重要。
