Clippe Christine, Ligneau Blandine, Trillet-Lenoir Véronique
Unité fonctionnelle d'oncologie médicale, Centre hospitalier Lyon-Sud, Hospices civils de Lyon, 69495 Pierre-Bénite.
Bull Cancer. 2002 Aug;89 Spec No:S120-2.
The therapeutic interest of gemcitabine both as a single drug and in combination is now well known and applied in various malignant diseases. However, it would be worth being further explored in two tumor models for which its efficacy has been suspected and which have been somehow "abandoned" by modern oncology after the demonstration of their high sensitivity to platinum derivatives, namely epidermoid tumours of the upper aero-digestive tract and uterine cervix. Combination studies should be encouraged in this setting.
吉西他滨作为单一药物或联合用药的治疗价值如今已广为人知，并应用于多种恶性疾病。然而，在两种肿瘤模型中它仍值得进一步探索，这两种肿瘤模型对铂类衍生物高度敏感，在证明这一点之后，现代肿瘤学在某种程度上已“放弃”了它们，即上呼吸消化道和子宫颈的表皮样肿瘤。在这种情况下，应鼓励开展联合研究。
