Kosanovic Melita, Jokanovic Milan, Jevremovic Milan, Dobric Silva, Bokonjic Dubravko
Faculty of Medicine, UAE Univeristy, Al Ain, United Arab Emirates.
Biol Trace Elem Res. 2002 Nov;89(2):97-103. doi: 10.1385/BTER:89:2:97.
Cadmium and selenium concentrations in maternal and umbilical cord blood and amniotic fluid were determined in 37 normotensive and 23 hypertensive women during the last trimester of pregnancy in relation to their smoking status. Thiocyanate concentration in plasma was used as the index of smoking status. Cadmium and selenium were determined with atomic absorption spectrometry (graphite furnace and mercury hydride system). In the group of normotensive and hypertensive women, significantly higher cadmium and lower selenium concentrations in blood in smokers were observed than in nonsmokers. Umbilical cord blood selenium concentrations in both normotensive and hypertensive smokers were significantly lower than in nonsmokers as well. In the group of normotensive women, significant differences in selenium concentrations in amniotic fluid were observed between smokers and non-smokers. In conclusion, the results of this study show that hypertension in pregnant women smokers is related to significantly higher blood cadmium concentrations, which indicates that cadmium may be considered as an independent factor involved in hypertension.
在37名血压正常和23名高血压孕妇妊娠晚期，根据她们的吸烟状况，测定了母血、脐血和羊水中镉和硒的浓度。血浆中硫氰酸盐浓度用作吸烟状况指标。采用原子吸收光谱法（石墨炉和氢化物系统）测定镉和硒。在血压正常和高血压女性组中，吸烟者血液中的镉浓度显著高于非吸烟者，而硒浓度则显著低于非吸烟者。血压正常和高血压吸烟者的脐血硒浓度也显著低于非吸烟者。在血压正常的女性组中，吸烟者和非吸烟者羊水中的硒浓度存在显著差异。总之，本研究结果表明，吸烟孕妇的高血压与血液中镉浓度显著升高有关，这表明镉可能被视为与高血压有关的一个独立因素。
