Sikorski R, Radomański T, Paszkowski T, Skoda J
Institute of Obstetrics and Gynecology, Academy of Medicine, Lublin, Poland.
J Perinat Med. 1988;16(3):225-31. doi: 10.1515/jpme.1988.16.3.225.
The association between maternal smoking and both morphometric birth parameters and the perinatal cadmium burden were studied. The cadmium concentrations were measured by atomic absorption spectrometry in 100 samples of maternal whole blood (MB) and in 93 samples of umbilical cord blood (CB). In the group of nonsmokers, significantly higher birth weight and decreased relative placental weight were noted as compared to the group of smokers who smoked more than 6 cigarettes a day (p less than 0.05). In both maternal and cord blood samples, the measured Cd levels were found to be significantly higher in smokers than in the nonsmoking subjects (for MB and CB p less than 0.01 and p less than 0.01 respectively). The average number of cigarettes smoked daily by the women had little effect on the levels of the metal. The Cd-MB strongly correlated with the Cd-CB (p less than 0.001). The cadmium values determined in MB and CB did not significantly affect any of the studied fetoplacental parameters. The reported findings give support for placental permeability to cadmium in humans and confirm that smoking during pregnancy leads to elevated Cd concentrations in both the mother and the fetus.
研究了孕妇吸烟与形态学出生参数及围产期镉负荷之间的关联。通过原子吸收光谱法测定了100份孕妇全血（MB）样本和93份脐带血（CB）样本中的镉浓度。与每天吸烟超过6支的吸烟者组相比，非吸烟者组的出生体重显著更高，胎盘相对重量降低（p<0.05）。在孕妇和脐带血样本中，吸烟者的镉水平均显著高于非吸烟受试者（MB和CB的p值分别<0.01和<0.01）。女性每天吸烟的平均数量对金属水平影响不大。MB中的镉与CB中的镉高度相关（p<0.001）。在MB和CB中测定的镉值对任何研究的胎儿-胎盘参数均无显著影响。报告的研究结果支持了镉在人体中的胎盘通透性，并证实孕期吸烟会导致母亲和胎儿体内的镉浓度升高。
