Serwin Agnieszka Beata, Waşowicz Wojciech, Gromadzińska Jolanta, Chodynicka Bozena
Department of Dermatology and Venereology, Medical Academy, Bialystok, Poland.
Biol Trace Elem Res. 2002 Nov;89(2):127-37. doi: 10.1385/BTER:89:2:127.
The aim of the study was to examine the influence of alcohol consumption on the severity of psoriasis and selenium (Se) concentration and Se-dependent gluathione peroxidase activity in plasma (pl-GSH-Px) and in erythrocytes (RBC-GSH-Px) in psoriatic patients. Thirty-five in-patients with psoriasis lasting <10 mo and 42 with psoriasis lasting >3 yr constituted groups 1 and 2, respectively. The severity of psoriasis was assessed using the PASI scoring system and the consumption of alcohol, using a structured questionnaire. The Se concentration was 47.11+/-11.61 microg/L in group 1 and 38.69+/-13.22 microg/L in group 2 (p<0.05), the pl-GSH-Px was 0.15+/-0.04 U/mL and 0.14+/-0.04 U/mL (p>0.05), and the RBC-GSH-Px was 13.97+/-4.27 U/g Hb and 13.16+/-3.85 U/g Hb (p>0.05), respectively. In excessive drinkers (<10% of patients, all males), the Se concentration was 32.84+/-10.88 microg/L, the pl-GSH-Px was 0.15+/-0.03 U/mL, and the RBC-GSH-Px was 11.64+/-3.32 U/g Hb. A low RBC-GSH-Px correlated to the consumption of high-grade alcoholic beverages (R=-0.45, p<0.05) and to the PASI value (R=-0.37, p<0.05) in group 2. Depressed Se concentration and Se-dependent GSH-Px can be related to the severity and a duration of psoriasis. The excessive consumption of alcohol is associated with severity of the disease and with low activity of GSH-Px in erythrocytes in patients with long-lasting psoriasis.
本研究旨在探讨饮酒对银屑病严重程度以及银屑病患者血浆（pl-GSH-Px）和红细胞（RBC-GSH-Px）中硒（Se）浓度及硒依赖性谷胱甘肽过氧化物酶活性的影响。35例病程小于10个月的银屑病住院患者和42例病程大于3年的银屑病患者分别构成第1组和第2组。采用PASI评分系统评估银屑病严重程度，通过结构化问卷评估饮酒情况。第1组的硒浓度为47.11±11.61μg/L，第2组为38.69±13.22μg/L（p<0.05）；pl-GSH-Px分别为0.15±0.04U/mL和0.14±0.04U/mL（p>0.05）；RBC-GSH-Px分别为13.97±4.27U/g Hb和13.16±3.85U/g Hb（p>0.05）。在过度饮酒者中（占患者不到10%，均为男性），硒浓度为32.84±10.88μg/L，pl-GSH-Px为0.15±0.03U/mL，RBC-GSH-Px为11.64±3.32U/g Hb。在第2组中，低RBC-GSH-Px与高档酒精饮料的摄入量（R=-0.45，p<0.05）以及PASI值（R=-0.37，p<0.05）相关。硒浓度降低和硒依赖性谷胱甘肽过氧化物酶可能与银屑病的严重程度和病程有关。过度饮酒与病程较长的银屑病患者的疾病严重程度以及红细胞中谷胱甘肽过氧化物酶活性降低有关。
