银屑病患者的硒状态及其与疾病病程和严重程度的关系。

Selenium status in psoriasis and its relations to the duration and severity of the disease.

作者信息

Serwin Agnieszka B, Wasowicz Wojciech, Gromadzinska Jolanta, Chodynicka Bozena

机构信息

Department of Dermatology and Venereology, Medical Academy, Bialystok, Poland.

出版信息

Nutrition. 2003 Apr;19(4):301-4. doi: 10.1016/s0899-9007(02)01081-x.

DOI:10.1016/s0899-9007(02)01081-x

PMID:12679161

Abstract

OBJECTIVE

We examined the role of selenium (Se) status in psoriasis and its relation to the severity and duration of the disease.

METHODS

The study was conducted among 30 patients with psoriasis of less than 10 mo duration (study group 1, sg 1) and 30 with psoriasis of more than 3 y duration (study group 2, sg 2). Control groups (cg) consisted of 30 patients with short periods of skin disorders other than psoriasis and 24 healthy volunteers (cg 1 and cg 2, respectively). Plasma Se concentration and glutathione peroxidase (GSH-Px) activity in plasma and erythrocytes were measured to determine Se status.

RESULTS

Plasma Se (microg/L) levels were 47.11 +/- 11.61 in sg 1, 38.69 +/- 13.22 in sg 2, 43.53 +/- 11.73 in cg 1, and 48.71 +/- 9.39 in cg 2; plasma GSH-Px (U/mL) levels, were 0.15 +/- 0.04, 0.14 +/- 0.04, 0.16 +/- 0.04, and 0.18 +/- 0.03, respectively; and erythrocyte GSH-Px (U/g of hemoglobin) levels were 13.97 +/- 4.27, 13.16 +/- 3.85, 14.25 +/- 3.84, and 14.35 +/- 3.35, respectively. Erythrocyte GSH-Px correlated inversely to severity of psoriasis in sg 2 (r = -0.37, P < 0.05).

CONCLUSION

Se status is depressed and related to the severity of the disease only in patients with psoriasis lasting more than 3 y.

摘要

目的

我们研究了硒（Se）状态在银屑病中的作用及其与疾病严重程度和病程的关系。

方法

该研究在30例病程小于10个月的银屑病患者（研究组1，sg 1）和30例病程超过3年的银屑病患者（研究组2，sg 2）中进行。对照组（cg）分别由30例患有除银屑病外短期皮肤疾病的患者和24名健康志愿者（分别为cg 1和cg 2）组成。测量血浆硒浓度以及血浆和红细胞中的谷胱甘肽过氧化物酶（GSH-Px）活性以确定硒状态。

结果

sg 1组血浆硒（μg/L）水平为47.11±11.61，sg 2组为38.69±13.22，cg 1组为43.53±11.73，cg 2组为48.71±9.39；血浆GSH-Px（U/mL）水平分别为0.15±0.04、0.14±0.04、0.16±0.04和0.18±0.03；红细胞GSH-Px（U/g血红蛋白）水平分别为13.97±4.27、13.16±3.85、14.25±3.84和14.35±3.35。sg 2组中红细胞GSH-Px与银屑病严重程度呈负相关（r = -0.37，P < 0.05）。