Akinboro Adeolu Oladayo, Mejiuni David Ayodele, Onayemi Olaniyi, Ayodele Olugbenga Edward, Atiba Adeniran Samuel, Bamimore Gbenga Micheal
Dermatology Unit, Department of Internal Medicine, College of Health Sciences, Osogbo, and LAUTECH Teaching Hospital, Ogbomoso, Oyo State, Nigeria.
HIV AIDS (Auckl). 2013 Aug 20;5:215-21. doi: 10.2147/HIV.S46364. eCollection 2013.
The role of selenium as an antioxidant micronutrient has garnered the unprecedented focus of researchers in recent times. No clinical study has related serum selenium concentration to skin diseases in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients.
In this study, 134 newly diagnosed HIV patients that satisfied the inclusion criteria were included. Skin diseases were clinically diagnosed and fasting venous blood was taken for assessment of serum selenium using an atomic absorption spectrophotometer.
THE MEAN AGE OF HIV SUBJECTS WITH AND WITHOUT SKIN DISEASE WERE NOT SIGNIFICANTLY DIFFERENT: 32.72 ± 9.21 versus 35.86 ± 8.55 years, P = 0.077, respectively. The mean of serum selenium (0.51 ± 0.48 versus 0.81 ± 0.39), CD4+ count (228.06 ± 212.89 versus 446.41 ± 182.87), and body mass index (BMI; 21.09 ± 3.58 versus 23.53 ± 3.35) were significantly lower (P < 0.001) for HIV/AIDS participants with skin disease than those without skin disease. We found significant clustering of symptoms and signs: fever (P = 0.037), weight loss (P = 0.009), oral candidiasis (P = 0.038), pallor (P = 0.037) among HIV/AIDS subjects with skin diseases than those without. Low serum selenium concentration was significantly associated with primary skin disease of HIV/AIDS, such as pruritic papular eruption of AIDS (P = 0.003), xeroderma (P = 0.030), fluffy hair (P = 0.021), blue-black nail hyperpigmentation (P = 0.033) and secondary skin disease, such as oral candidiasis (P = 0.002). There was a significant association between low serum selenium concentration and increasing frequency of skin diseases (P = 0.002), but serum selenium was not significantly related to extents of distribution of skin diseases (P > 0.05).
serum selenium concentration was lower among HIV subjects with skin diseases than those without skin disease. Pruritic papular eruption, xeroderma, fluffy hair, blue-black nail hyper pigmentation, and oral candidiasis were significantly associated with low serum selenium concentration.
近年来，作为一种抗氧化微量营养素，硒的作用获得了研究人员前所未有的关注。尚无临床研究将血清硒浓度与人类免疫缺陷病毒（HIV）/获得性免疫缺陷综合征（AIDS）患者的皮肤疾病相关联。
本研究纳入了134名符合纳入标准的新诊断HIV患者。对皮肤疾病进行临床诊断，并采集空腹静脉血，使用原子吸收分光光度计评估血清硒。
患有和未患有皮肤疾病的HIV患者的平均年龄无显著差异：分别为32.72±9.21岁和35.86±8.55岁，P = 0.077。患有皮肤疾病的HIV/AIDS参与者的血清硒平均值（0.51±0.48对0.81±0.39）、CD4 +细胞计数（228.06±212.89对446.41±182.87）和体重指数（BMI；21.09±3.58对23.53±3.35）均显著低于未患有皮肤疾病的参与者（P <0.001）。我们发现症状和体征存在显著聚集：患有皮肤疾病的HIV/AIDS受试者出现发热（P = 0.037）、体重减轻（P = 0.009）、口腔念珠菌病（P = 0.038）、面色苍白（P = 0.037）的情况比未患有皮肤疾病的受试者更常见。低血清硒浓度与HIV/AIDS的原发性皮肤疾病显著相关，如艾滋病瘙痒性丘疹疹（P = 0.003）、皮肤干燥症（P = 0.030）、毛发蓬松（P = 0.021）、蓝黑色甲色素沉着（P = 0.033）以及继发性皮肤疾病，如口腔念珠菌病（P = 0.002）。低血清硒浓度与皮肤疾病发生频率增加之间存在显著关联（P = 0.002），但血清硒与皮肤疾病的分布范围无显著相关性（P>0.05）。
患有皮肤疾病的HIV受试者的血清硒浓度低于未患有皮肤疾病的受试者。瘙痒性丘疹疹、皮肤干燥症、毛发蓬松、蓝黑色甲色素沉着和口腔念珠菌病与低血清硒浓度显著相关。
